TORONTO -- The Toronto Blue Jays survived their first elimination game of the postseason on Tuesday by defeating the Cleveland Indians 5-1 in Game 4 of the American League Championship Series.Now they must try to do it again in Game 5 on Wednesday at Rogers Centre.Blue Jays manager John Gibbons has given the assignment to right-hander Marco Estrada, who took the loss in Game 1 despite pitching Torontos only complete game of the season -- a 2-0 loss to Corey Kluber.The Indians will go with left-handed rookie Ryan Merritt, who will be making his postseason debut after spending most of the season at Triple-A Columbus.The Blue Jays five runs Tuesday were more than they had scored in the three previous games combined (three). It helped when a home run by Josh Donaldson gave them a 1-0 lead in the third and an RBI flare single by Ezequiel Carrera in the fourth gave them a 2-0 lead.You know, I liked being able to get the lead there early on in the game, Donaldson said. We havent been able to get a lead in this series. And I felt like it was very important for us to get out to a lead. And even if it was one run, whatever. ... In the playoffs, these games arent going to come easy to win. Theyve played great defense. Theyve pitched well and had timely hits.The Indians were able to get through Tuesday without using their two best relievers, right-hander Cody Allen and left-hander Andrew Miller. Both played vital roles in the first three games of the series. They will be rested for Game 5.I think that helps, Indians manager Terry Francona said. Certainly when youre down one trying to keep it at one so we have a chance, but also recognizing that if Miller and Cody pitch, that would have been four out of five pretty high-stress, high-leverage innings.(I) decided to try to go a different route. Didnt work out as well as we wanted, but we do have those guys available with a day off behind it.Edwin Encarnacion added a two-run single and Kevin Pillar had a sacrifice fly.Blue Jays manager John Gibbons felt like his team approached the game like they normally would.Really, everything, almost like a normal day, Gibbons said. Obviously its not, but it was almost like a normal regular-season game. They were nice, loose and relaxed, well aware of the circumstances. They showed up today like they always do and played a good ballgame.Francona was down 3-0 in the 2004 ALCS when he was managing the Boston Red Sox. They became the first major-league team to come back from a 3-0 disadvantage, beating the New York Yankees in seven games. They then went on to win the World Series.Im proud of that, obviously, Francona said before the game Tuesday. That was a wonderful four days. I dont think the first three were that great. But it ended -- it was fun to live through that and to actually live. So I guess if people ask, I dont mind it, because like I said, I was proud of those guys. ... But this is a different time, a different team, very different circumstances.Merritt has pitched in four regular-season games, including one start, and is 1-0 with a 1.64 ERA. In 24 starts at Columbus, he was 11-8 with a 3.70 ERA.If you told me at the start of the season I was going to be pitching in the ALCS, I wouldve thought you were crazy, Merritt said. Its awesome. Im glad its here.Estrada allowed two runs in eight innings in the 2-0 loss in Game 1 at Progressive Field. He allowed six hits and one walk and struck out six.In his regular-season start against Cleveland this season, he allowed three runs in five innings. In two career regular-season starts vs. Cleveland, he is 0-0 with a 3.75 ERA.Weve got to win, Estrada said. Thats basically it. Im going to go out and do what Ive basically done all year and not really think about it as an elimination game. 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Thousands of fans at Mosaic Stadium will be cozying up to each other in an effort to stay warm in chilly temperatures and block the Prairie wind that locals say can knock your socks off. The Ice Bucket Challenge is being credited with helping to raise significant funds that have allowed researchers to identify a gene found to be one of the most common in people with ALS, the deadly disease that affects neurons in the brain and spinal cord.The Challenge became a sensation two summers ago and involved participants, including many athletes and celebrities, pouring ice water over their heads to help raise awareness of amyotrophic lateral sclerosis, better known as Lou Gehrigs disease.The effort raised more than $100 million in contributions for the ALS Association, which contributed $1 million to the Project MinE research project.The ALS Ice Bucket Challenge enabled us to secure funding from new sources in new parts of the world, said Bernard Muller, an entrepreneur who suffers from the progressive disease and helped start the research project. This transatlantic collaboration supports our global gene hunt to identify the genetic drivers of ALLS.ddddddddddddIm incredibly pleased with the discovery of the NEK1 gene adding another step towards our ultimate goal, eradicating this disease from the face of the earth.The research, detailed in a paper published this week by Nature Genetics, has found NEK1 to be present in 3 percent of cases in North America and and Europe. That discovery will help scientists in understanding the disease and developing new therapies.Pete Frates, a former Boston College baseball star suffering from ALS, was a driving force behind the Ice Bucket Challenge becoming such a huge fundraising success and himself was doused during a ceremony at Fenway Park.Others who were doused for the cause included LeBron James, former President George W. Bush and Ronda Rousey. 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